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• February 17, 2023

Comparison of nasal intermittent positive pressure ventilation and bubble CPAP with an in-line high-frequency interrupter in a premature infant lung model

Comparison of nasal intermittent positive pressure ventilation and bubble CPAP with an in-line high-frequency interrupter in a premature infant lung model

Noninvasive ventilation has become a staple in the care of premature infants. However, failure rates continue to be challenging. Modifications to noninvasive support, such as nasal intermittent positive pressure ventilation (NIPPV), may be used to reduce such failure. In this study, authors used simulation model of a premature lung to compare carbon dioxide (CO2) clearance with using NIPPV versus using bubble CPAP with an in-line high-frequency interrupter (HFI). They connected the premature lung model to a Dräger VN500 for delivery of NIPPV or a bubble CPAP device with superimposed high-frequency oscillations generated by an in-line HFI. They found that superimposing HF oscillations onto bubble CPAP with an in-line HFI resulted in improved CO2 clearance relative to bubble CPAP alone for all tested oscillation frequencies at all CPAP levels (p < 0.001). NIPPV also resulted in improved CO2 clearance relative to nasal CPAP alone (p < 0.001). Authors concluded that superimposing high-frequency oscillations onto bubble CPAP circuit using in-line HFI may be effective at clearing CO2 than NIPPV in a premature infant lung model. Such intervention need to be examined in-vivo to ensure its safety prior to generalization of the concept. Rub DM, Sivieri EM, Abbasi S, Sieberlich W, Eichenwald EC. Comparison of nasal intermittent positive pressure ventilation and bubble CPAP with an in-line high-frequency interrupter in a premature infant lung model. Pediatr Pulmonol. 2022 Oct;57(10):2356-2362. doi: 10.1002/ppul.26039. Epub 2022 Jun 29. PMID: 35722805. Read more: https://pubmed.ncbi.nlm.nih.gov/35722805/

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The Bubble CPAP Institute is an interactive educational platform aiming to make the knowledge and skill set of Bubble CPAP accessible to practitioners who care for neonates and young infants across the globe. This platform will primarily focus on the know-how and will offer educational modules on issues like when to consider bCPAP in managing infants with respiratory distress, how to assemble the bCPAP circuits, how to apply the nasal interface and how to troubleshoot bedside issues.

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